Highlights
Age Groups Seen
- Adult
Languages
- English
Gender
FemaleAbout Mary Rensel
Title
Director of Wellness at the Mellen Center
Biography
Mary Rensel, MD is an Associate Professor of Medicine at the Cleveland Clinic Lerner College of Medicine and Director of Pediatric Multiple Sclerosis and Wellness at the Mellen Center of the Cleveland Clinic. She has graduated from the Medical College of Ohio and completed her Neurology and Neuro-immunology fellowship training at the Cleveland Clinic. She is boarded in Neurology and Integrative Medicine and is a fellow of the American Academy of Neurology. Dr. Rensel’s work has focused on Adult and Pediatric Multiple Sclerosis, Brain health and Integrative Medicine. Her work in academic medicine often intersects with wellness, advocacy, innovation and strategic initiatives. She serves on the steering committee of the National Network of Pediatric MS Centers. She is a “Best Doctor” of Cleveland since 2010 per the Cleveland Magazine. She has served as President of the Women’s Professional Staff Association of the Cleveland Clinic and sits on multiple boards including the Ohio National Multiple Sclerosis Society. She is active as a coach, mentor, scientific reviewer, clinical researcher, activity director, entrepreneur and national speaker. She has also appeared on numerous media outlets, including a spot on Good Morning America.
Dr. Rensel has had articles and abstracts published in peer-reviewed medical journals and has written chapters: "Differential Diagnosis of MS and Clues to Misdiagnosis," in the book entitled Multiple Sclerosis: Diagnosis, Medical Management and Rehabilitation as well as "General Health and Wellness in MS" in the book entitled Multiple Sclerosis and Related Disorders.
Locations
- Hillcrest Hospital
- 6780 Mayfield Road, Mayfield Hts, OH 44124
- Get Directions
- U Building - Mellen Center
- 1950 East 89th Street, Cleveland, OH 44106
- Get Directions
- U Building - Mellen Center
- 1950 East 89th Street, Cleveland, OH 44106
- Get Directions
- Twinsburg Family Health and Surgery Center
- 8701 Darrow Road, Twinsburg, OH 44087
- Get Directions
Education & Board Certifications
Education
- Fellowship: Cleveland Clinic, 1998
- Residency: Cleveland Clinic, 1996
- Internship: Cleveland Clinic, 1993
- Medical Education: Medical College of Ohio at Toledo, 1992
- Undergraduate: Gannon University, 1988
Board Certifications
- Neurology: American Board of Psychiatry & Neurology, 1997
Professional Highlights
- Network of Pediatric MS Centers Steering Committee
- Director of Pediatric MS, Mellen Center
- Director of Wellness, Mellen Center
- Principal Investigator of Clinical trials
- President of Women's Professional Staff Association 2017-2019
- International Pediatric MS Study Group 2011- Present
Additional Training
- Quality as Value in Healthcare: What do current changes mean? 11/1/12
- Resonant Leadership: Creating Sustainable Leaders Through Mindfulness, Hope & Compassion, 9/11/12
- Middle East Cultural Competence: Culture, Patient Care and Working Relationships
- The Business of Healthcare, 10/12/11
- Foundations of Healthcare Communication for Physicians, 9/13/11
- Investigator Human Subject Research Education track 2/17/10
- Cleveland Clinic Staff Mentorship training 1/ 2010
- Palatucci Patient Advocacy training 1/2011
- Engaging Women Leaders: Setting Your Goals , 3/3/09
- The Science and Clinical Application of Integrative Holistic Medicine , San Diego, CA 11/16-21/08
- Using Sharepoint CCA 7/24/08
- Situational Leadership CCA 7/1/08
- Tools and Tips for Information Management , 10/21/08
- Patient Experience Within the Revenue Cycle, 11/25/08
- Writing Educational Objectives, Cleveland Clinic, 2006
- What the CEO Wants you to Know: Building Business Acumen, Physician Leadership University, Cleveland Clinic, 2006
- Process Improvement, Physician Leadership University, Cleveland Clinic, 2006
- Essentials of Clinical Teaching and Assessment Retreat, Cleveland Clinic, 2006
- Biostatics and Statistical Computing, Cleveland Clinic, 2002
- Research Methods Module I, Clinical Epidemiology, Cleveland Clinic, 2002
- Human Research Subjects Protection Training, Cleveland Clinic, 2002
Awards
- Clinical Neurology Award, Medical College of Ohio, 1992
- Alumni of the Year, St. Francis of Assisi, 2003
- Distinguished Educator Level I Certificate, ClevelandClinic, 2007
- Best Doctors of Cleveland, Cleveland Magazine, 2010-present
- Caregiver Celebration Award, Cleveland Clinic, 2013,2014
- Mentor Recognition Award, Cleveland Clinic, 2015
- Service award for Career Development and Coaching, Cleveland Clinic, 2016
- Outstanding preceptor for Medical students, Cleveland Clinic, 2019
Professional Memberships
Innovations & Patents
BrainMAX
Research & Publications
See publications for this provider. (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)
Industry Relationships
Cleveland Clinic physicians and scientists collaborate with industry to advance medical breakthroughs. These partnerships help commercialize discoveries for public benefit while maintaining scientific integrity. To ensure transparency and minimize potential bias, Cleveland Clinic reviews these relationships and publicly discloses when physicians/scientists receive significant compensation for consulting, serve in fiduciary roles, receive royalties, or hold equity interests related to their work. We manage potential conflicts through approval processes, annual reporting, and targeted management plans.
As of 2025-11-14, Dr. Rensel has reported the financial relationships with the companies listed below.
Fiduciary Role. Dr. Rensel serves in a fiduciary capacity, such as an elected officer, director or chief medical officer, for the following companies or other entities:
- Brain Fresh, LLC
Consulting and/or Speaking. Dr. Rensel receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:
- Roche (Hoffman-La Roche, Ltd.)
- EMD Serono, Inc.
- TG Therapeutics, Inc.
Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.
* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.
Insurances Accepted
Video
Ratings & Reviews
4.9 out of 5
100 ratings, 20 reviewsThe Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
- 5 out of 5 starsReviewed on 3/11/2026
Dr. Mary Rensel is the BEST doctor ever.
- 5 out of 5 starsReviewed on 3/11/2026
I really liked the interaction with the Dr She made me feel comfortable
- 5 out of 5 starsReviewed on 2/24/2026
Dr. Rensel is an excellent doctor. She is always available, in some form, when needed.
- 5 out of 5 starsReviewed on 2/24/2026
Dr. Rensel is amazing! She makes me feel as though she cares. She walked thru my diagnosis with me point by point and step by step. She never makes me feel as though she has somewhere else to be. She explained the treatment she suggested In full and why, Including the side effects that I could expect. She''s hands down one of the (very rare) best doctors I''ve ever had. I live 2 hours away from her practice and have no intention of finding another doctor.
- 5 out of 5 starsReviewed on 2/6/2026
Dr Rensel was very open and helpful with getting next steps ordered for rests and physical therapy to get started to help relieve symptoms
- 5 out of 5 starsReviewed on 1/27/2026
Dr Rensel is a top notch physician , neurologist and human being . One of the best drs I've been to .
- 5 out of 5 starsReviewed on 1/12/2026
Dr Rensel is a very good Dr.I always have a good experience at their office.
- 5 out of 5 starsReviewed on 1/12/2026
Love my Doctor!!!!
- 5 out of 5 starsReviewed on 12/9/2025
If there is ever a time that I know someone that could possibly have MS, I definitely would recommend they visit Dr. Rensel for treatment.
- 5 out of 5 starsReviewed on 12/9/2025
Dr. Rensel went above and beyond to help me, from the very first time we spoke, ordering test and our in person appointment. I am extremely blessed that I don't have MS. I continue to seek answers for what autoimmune disease I have that has affected my health so negative for such an extended amount of years.
- 5 out of 5 starsReviewed on 12/9/2025
Dr. Rensel is wonderful. She always listens to me and HEARS what I am saying. I am so glad that she is my doctor.
- 5 out of 5 starsReviewed on 11/10/2025
I had a really good experience, The doctor spent a great deal of time with me. I appreciated that she was quite thorough. I thought.
- 5 out of 5 starsReviewed on 10/21/2025
I was actually with my doctor the entire visit, which was important to me. She was absolutely great
- 5 out of 5 starsReviewed on 9/23/2025
She was excellent making sure I understood the My Chart message that was my concern
- 5 out of 5 starsReviewed on 8/28/2025
Dr Resel is world class! She is very compassionate and gave me details on treatment and peace of mind! Her assistant was attentive and very thorough! I love both of them!
- 5 out of 5 starsReviewed on 7/29/2025
She took so much time to walk me through every part of the mri and answer all of my questions. She was patient and caring... One of the best medical experiences I had. Thank you
- 5 out of 5 starsReviewed on 6/26/2025
Dr Rensel was AMAZING. So caring, knowledgeable, calm and respectful. One of the best medical experiences I have ever had.
- 5 out of 5 starsReviewed on 6/16/2025
Sincere dr and staff
- 5 out of 5 starsReviewed on 5/20/2025
Dr. Rensel always remembers things about me that I have done in the past. She is a caring, kind person. I'm thankful she has been my doctor for so many years!
- 5 out of 5 starsReviewed on 5/20/2025
Dr. Rensel is very easy to talk with and fills you in on new advancement and care options.