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Matthew Deren

Matthew Deren, MD

Hip and Knee Orthopedic SurgeryReconstructive Orthopedic Surgery

Need help scheduling? Call (216) 444-2606

Highlights

Age Groups Seen

  • Adult

Languages

  • English

Gender

Male

About Matthew Deren

Biography

Matthew Deren, MD is a board-certified orthopaedic surgeon in the Division of Adult Reconstruction. He specializes in knee and hip replacement surgeries, including direct anterior total hip replacement, robotic-assisted total and partial knee replacements, as well as complex and revision knee and hip replacements. He sees patients at Mentor Hospital, Euclid Hospital and Main Campus. He is also the Fellowship Director of the Adult Reconstruction Fellowship at the Cleveland Clinic.

Dr. Deren completed his undergraduate studies at Yale University, followed by medical school at the Alpert Medical School of Brown University. He then continued his training with orthopaedic residency at Brown University and Rhode Island Hospital where he received the Haffenreffer Housestaff Excellence Award as one of the best chief residents in the entire medical system. He then completed an orthopaedic trauma fellowship at Brown University and Rhode Island Hospital, followed by a fellowship in Adult Reconstruction at the Cleveland Clinic in 2018. In 2022, Dr. Deren returned to the Cleveland Clinic as a Staff Orthopaedic Surgeon after practicing at the University of Massachusetts School of Medicine. In his free time, he enjoys fishing, hunting, woodworking, and spending time with his family. 

Locations

  1. A Building - Crile Building
    • phone:
    • fax:
  2. Mentor Hospital
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  3. Euclid Medical Office Building
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    • fax:

Education & Board Certifications

Education

  • Fellowship: Cleveland Clinic, 2018
  • Fellowship: Rhode Island Hospital, 2017
  • Residency: Rhode Island Hospital, 2016
  • Medical Education: Brown University, 2011

Board Certifications

  • Orthopaedic Surgery: American Board of Orthopaedic Surgery, 2022

Awards

  • Distinguished Teacher of the Year Award, University of Massachusetts Orthopedic Surgery Residency Program, 2021
  • Haffenreifer Housestaff Excellence Award, Rhode Island Hospital, 2016

Professional Memberships

American Association of Hip and Knee Surgeons; American Association of Orthopaedic Surgeons

Research & Publications

See publications for this provider. (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Cleveland Clinic physicians and scientists collaborate with industry to advance medical breakthroughs. These partnerships help commercialize discoveries for public benefit while maintaining scientific integrity. To ensure transparency and minimize potential bias, Cleveland Clinic reviews these relationships and publicly discloses when physicians/scientists receive significant compensation for consulting, serve in fiduciary roles, receive royalties, or hold equity interests related to their work. We manage potential conflicts through approval processes, annual reporting, and targeted management plans.

As of 2025-09-26, Dr. Deren has reported the financial relationships with the companies listed below.

Consulting and/or Speaking. Dr. Deren receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Brasseler USA Surgical
  • Stryker Corporation

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Insurances Accepted

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

Video

Ratings & Reviews

4.8 out of 5

280 ratings, 37 reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

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Patient Rating of Doctor
Search reviews
    5 out of 5 stars
    Reviewed on 4/6/2026

    In fact, after listening to my concerns and further viewing my x-rays and CT Scan, the doctor referred me to the Spine Center on Main Campus. But to date, I have been unable to schedule an appointment with Dr. Hsia there because the referral from Dr. Deren did not include a specific diagnosis.

    5 out of 5 stars
    Reviewed on 3/20/2026

    Unfortunately, I have experience. But this experience lets me know that I would highly recommend Dr. Deren.

    5 out of 5 stars
    Reviewed on 3/20/2026

    Dr. Deren listened carefully to my discussion of my problems with both knees. I am now on his panel and will schedule a follow up visit as needed

    5 out of 5 stars
    Reviewed on 2/20/2026

    Took awhile to get initial appointment, but Dr. Deren got me in for surgery very promptly. I had extenuating personal circumstances and he came through for me.

    5 out of 5 stars
    Reviewed on 2/20/2026

    Dr Deren is great. Issues were through MyChart arranging the video meeting.

    5 out of 5 stars
    Reviewed on 2/9/2026

    Dr Mathew Deren is the best and I've already recommended him to several friends.

    5 out of 5 stars
    Reviewed on 1/26/2026

    Dr. Deren and his team have operated and led me through two successful knee surgeries. I highly recommend them.

    5 out of 5 stars
    Reviewed on 11/19/2025

    I love Dr. Daren and his whole team! I have found the orthopedic for me. Recommend him to everyone

    5 out of 5 stars
    Reviewed on 11/19/2025

    Couldn't have been more pleased with Dr Deren. He was easy to talk to and answered all of my questions in a way that I was able to understand. I would recommend him for sure.

    5 out of 5 stars
    Reviewed on 11/19/2025

    Dr Deren and his staff are very professional and helpful. Jessica the nurse has always responded right away to any questions that I have had which is much appreciated. Brandon his PA is equally helpful.

    5 out of 5 stars
    Reviewed on 11/19/2025

    Dr Deren is the best. Listens closely, is compassionate, and obviously tremendously skilled. I have already recommended him to others. Thankful to have had him do my surgery.

    5 out of 5 stars
    Reviewed on 11/13/2025

    Good experience, felt my questions were answered completely and without the Dr being distracted.

    5 out of 5 stars
    Reviewed on 10/30/2025

    Dr. Deren took the time to answer my many post surgery questions.

    5 out of 5 stars
    Reviewed on 10/7/2025

    Love Dr Deren and staff

    5 out of 5 stars
    Reviewed on 9/24/2025

    Dr. Deren was very thorough in his time with me. He took the time to explain his findings in detail to both myself and my sister and answered all of our questions. We were both very pleased.

    5 out of 5 stars
    Reviewed on 9/19/2025

    DR Deren was easy to understand

    5 out of 5 stars
    Reviewed on 9/19/2025

    I GREATLY appreciate Dr. Deren's expertise, as I had NO pain after the surgery, which amazed nurses at Cleveland Clinic's Mentor Hospital. There was only soreness in muscles that had to be retracted to remove the osteopathic right hip.

    5 out of 5 stars
    Reviewed on 8/27/2025

    I have already recommended Dr. Deren to 2 people. Very knowledgeable and very nice.

    5 out of 5 stars
    Reviewed on 8/20/2025

    Dr. Deren is the best doctor! I feel very fortunate to have him as my doctor. He a wonderful doctor! Could not be better.

    5 out of 5 stars
    Reviewed on 8/20/2025

    This has been the Best experience in a hospital I ever have had. The Orthopedic doctor and my surgical doctor gave me a second chance at life, I just want to thank them so much for all the information and the surgery went well and I'm doing great after 19 years with an old Andry. I've got my life back and I appreciate it surgeon Matthew Darren it was a wonderful experience.

    5 out of 5 stars
    Reviewed on 8/20/2025

    Ive been in so much pain for 20 years, dr. Matthew Darren gave me a chance at life again, What a wonderful Doctor!

    5 out of 5 stars
    Reviewed on 8/20/2025

    Dr Deren Is great professionally. Total confidence that he communicated well to me and with compassion.

    5 out of 5 stars
    Reviewed on 8/19/2025

    Both PA and Doc Deren explained the cause of my hip pain and put a plan in motion to lessen the pain.

    5 out of 5 stars
    Reviewed on 7/14/2025

    Dr Deren is fantastic. Great surgeon with a good bedside manner (which is unusual with some surgeons, LOL). Definitely cares for his patients.

    5 out of 5 stars
    Reviewed on 7/2/2025

    My experience with Dr. Deren and his team has been excellent.

    5 out of 5 stars
    Reviewed on 7/2/2025

    No complaint Dr Derran and his Nurse was on point about my situation

    5 out of 5 stars
    Reviewed on 6/6/2025

    EXCELLENT care from Dr. Deren and Nurse Jessica, despite the two-hour wait.

    5 out of 5 stars
    Reviewed on 5/28/2025

    Excellent doctor

    5 out of 5 stars
    Reviewed on 5/28/2025

    Dr Derren & his staff are excellent! Highly recommend them

    5 out of 5 stars
    Reviewed on 5/22/2025

    Dr Deren and staff are the best I've encountered

    5 out of 5 stars
    Reviewed on 5/22/2025

    Great doctor

    5 out of 5 stars
    Reviewed on 5/22/2025

    Fantastic Dr.

    5 out of 5 stars
    Reviewed on 5/8/2025

    Dr. Deren was patient with questions, explained things thoroughly and listened closely. I felt reassured about my upcoming surgery.

    5 out of 5 stars
    Reviewed on 5/2/2025

    PA had Dr. Deren speak with me regarding knee and will definitely consider Dr. Deren when having surgery.

    5 out of 5 stars
    Reviewed on 4/25/2025

    Dr Deren is very through, he listens to my concerns, explains everything in a way that I can understand, provided me with a treatment plan and presented +/- to me about my knees. We also discussed the progress about my hip reconstruction. I am very pleased with my progress and my options for for my knees. He takes the time to listen and explain

    5 out of 5 stars
    Reviewed on 4/24/2025

    I will always go to Dr. Deren for any joint problems I have and I will recommend him to all friends who are needing orthopedic care.

    5 out of 5 stars
    Reviewed on 4/24/2025

    I had an infection after hip surgery done at a different hospital by a different physician. Dr. Deren saw me quickly and was able to get me in the hospital for surgery. I will be eternally thankful for him & Dr. Malloy's quick response to my need for surgery.