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Nizar Zein

Nizar Zein, MD

4.878 ratings, 9 reviews

Transplant HepatologyHepatologyGastroenterology

Need help scheduling? Call (216) 444-7000

Highlights

Age Groups Seen

  • Adult

Languages

  • Arabic
  • English

Gender

Male

About Nizar Zein

Biography

Dr Zein is the Chief of Hepatology and the inaugural endowed holder of the Mikati Foundation Chair in Liver Diseases. He received several awards, including the American Liver Foundation Scholar Award, the Cleveland Clinic Innovator Award and the Distinguished Faculty Award for Research Mentorship. He has been recognized for academic excellence by the Syrian American Medical Society and honored for his leadership and community service by the Ana G. Mendez University of Puerto Rico as the recipient of Presidential Medal in 2011. He was elected to the Board of Governors of the Cleveland Clinic in 2015.

Dr Zein’s research focuses on improving disease and treatment outcome in patients with the Hepatitis C virus before and after liver transplantation.  He has authored over 200 publications, and has been the Principal Investigator of several large clinical trials. He holds several patents and established a research group at Cleveland Clinic focused on 3D printing of solid organs.

Dr. Zein is actively involved in the education of fellows and residents being trained at the Cleveland Clinic.  He has been recognized by the Cleveland Clinic Lerner College of Medicine Teacher of the Year, a distinction that reflects his commitment to the education and mentorship of young physicians.

Dr Zein has served as the Editor of “The Year in Gastroenterology and Hepatology” associate editor of the American Journal of Gastroenterology, Special Section Editor of “Liver Transplantation” and an editorial board member of Hepatology and Gastroenterology & Hepatology.

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Locations

  1. A Building - Crile Building
    • phone:
    • fax:
  2. A Building - Crile Building
    • phone:
    • fax:

Education & Board Certifications

Education

  • Fellowship: Mayo Clinic, 1996
  • Residency: Medical College of Ohio Hospitals, 1992
  • Internship: Medical College of Ohio Hospitals, 1989
  • Medical Education: MetroHealth Medical Center, 1988
  • Medical Education: Tishreen University Faculty of Medicine, 1986

Board Certifications

  • Gastroenterology: American Board of Internal Medicine, 1995

Professional Highlights

  • Chairman, Global Patient Services
  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation

Additional Training

  • Mayo Clinic Scholar 1996-1997

Awards

  • Medical College of Ohio most outstanding resident award 1992
  • Mayo Clinic J Arnold Bargen Award for outstanding achievement in Gastroenterology training 1996
  • American Liver Foundation Scholar Award 1997
  • Innovator Award, Cleveland Clinic 2004
  • Physician of the Year, Cleveland Clinic International Center 2005
  • Innovator Award, cleveland Clinic 2006
  • Academic Achievement Award, Syrian American Medical Society 2007
  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation 2007
  • Top Doctors in Cleveland, Cleveland Magazine 2007
  • Teacher of the year, Cleveland Clinic 2008

Professional Memberships

American College of Gastroenterology; American Gastroenterology Association; American Association for the Study of Liver Diseases; Syrian-American Medical Society

Innovations & Patents

  • NS5 and Core proteins in inducing protective antibodies, MMV # 99-073
  • Inhaled liposomal IL-2 in the treatment of chronic HCV infection, MMV # 01-022
  • Etanercept as an adjuvant to interferon and ribavirin for patients with chronic hepatitis C infection, MMV # 03-07
  • A novel assay using ascetic fluid Lactoferrin to diagnose spontaneous bacterial peritonitis and other bacterial infections in patients with liver cirrhosis (CCF, 2004)
  • Non-invasive diagnostic test (serum cytokeratin-18) for patients with suspected nonalcoholic fatty liver disease (serial # 60/801,728)

Research & Publications

See publications for this provider. (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Cleveland Clinic physicians and scientists collaborate with industry to advance medical breakthroughs. These partnerships help commercialize discoveries for public benefit while maintaining scientific integrity. To ensure transparency and minimize potential bias, Cleveland Clinic reviews these relationships and publicly discloses when physicians/scientists receive significant compensation for consulting, serve in fiduciary roles, receive royalties, or hold equity interests related to their work. We manage potential conflicts through approval processes, annual reporting, and targeted management plans.

As of 2025-11-03, Dr. Zein has reported the financial relationships with the companies listed below.

Consulting and/or Speaking. Dr. Zein receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • The View Hospital
  • Sectoral Asset Management

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Insurances Accepted

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

Video

Ratings & Reviews

4.8 out of 5

78 ratings, 9 reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

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Patient Rating of Doctor
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    5 out of 5 stars
    Reviewed on 4/13/2026

    Dr Z is the best!!

    5 out of 5 stars
    Reviewed on 4/7/2026

    Very thorough and professional. Was easy to understand. Very empathetic. Great Doctor

    5 out of 5 stars
    Reviewed on 3/30/2026

    The doctor was an excellent listener, and I appreciated his candid, constructive criticisms.

    5 out of 5 stars
    Reviewed on 1/12/2026

    Dr. Was focused and listened to me. He was to the point when talking to me.

    5 out of 5 stars
    Reviewed on 12/4/2025

    DR. ZEIN WAS TOP NOTCH. HE WAS KNOWLEDGABLE, KIND AND EXPLAINED EVERYTHING TO ME. MY RESULTS WERE AVAILABLE PROMPTLY AND HE SCHEDULED ME WITH 48 HOURS TO REVIEW THEM, EVEN THOUGH HE HAD A FULL SCHEDULE. HE TREATED ME THE EXACT WAY I NEEDED. I WOULD BE PROUD TO REFER HIM TO THOSE IN NEED.

    5 out of 5 stars
    Reviewed on 8/29/2025

    Best doc ever.

    5 out of 5 stars
    Reviewed on 7/15/2025

    Dr. Zein! I wish I could write him higher. Very forthright.

    5 out of 5 stars
    Reviewed on 7/8/2025

    My Dr is awesome!!

    5 out of 5 stars
    Reviewed on 7/8/2025

    Very pleased with care from Dr. Zein & Dr. Ahmed!