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Umesh N. Khot

Umesh N. Khot, MD

4.863 ratings, 5 reviews

Cardiology

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Highlights

Age Groups Seen

  • Adult

Languages

  • English

Gender

Male

About Umesh N. Khot

Biography

Umesh N. Khot, MD, is a Vice Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine, the Director of Regional Cardiovascular Medicine, and the Heart, Vascular and Thoracic Institute Chief Compliance Officer. He is a staff cardiologist in the Section of Clinical Cardiology in the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. His clinical specialties include coronary artery disease, heart attack care, heart valve disease and heart failure. He is board-certified in cardiovascular medicine and echocardiography.

A graduate of The Ohio State University College of Medicine, Dr. Khot completed a residency in internal medicine at Stanford University Medical Center followed by a fellowship in cardiovascular medicine at Cleveland Clinic. He was appointed to the medical staff in 2011.

Prior to his appointment to the Cleveland Clinic staff, Dr. Khot was director of the Noninvasive Vascular Laboratory with Indiana Heart Physicians and director of the EHART® STEMI Program at St. Francis Heart Center in Indianapolis. He also was a member of the Practice Executive Committee and a member of the St. Francis Heart Center Cardiac Operations Group. EHART® is a specialized triage and treatment protocol developed by Dr. Khot to reduce the time-to-treatment for heart attack patients who come to the emergency room. This protocol has led not only to improved time-to-treatment but also to an increased rate of survival after the heart attack. The American Heart Association and the American College of Cardiology have recognized this protocol as a major advance in heart attack care.

Dr. Khot is a world expert in the design of heart attack systems of care with his work being highlighted by multiple medical journals and the American Heart Association and the American College of Cardiology. He also has extensive experience in healthcare information technology, clinical operations, and financial management of complex healthcare systems. His work has been awarded the HIMSS Davies Award for best information technology project nationally, the State of Ohio Patient Safety Institute Best Practice Award, and the Best Achievement of Operational Excellence in Healthcare.

Dr. Khot is the author of a number of research articles in leading medical journals, including The New England Journal of Medicine, Journal of the American Medical Association (JAMA), Journal of the American College of Cardiology and Circulation. He has contributed to novel understanding of the role of vasodilator therapy in severe aortic stenosis, the association between risk factors and heart disease, and insights into outcomes in patients with myocardial infarction, heart failure, and heart surgery. His research has been cited within the practice guidelines of the American College of Cardiology, American Heart Association, and European Society of Cardiology. Dr. Khot has been a reviewer for JAMA, Circulation, American Heart Journal, Nature Practice Cardiovascular Medicine and American Journal of Cardiology. He is a Fellow of the American College of Cardiology. 

 Dr. Khot enjoys spending time with his four children, traveling, and exploring the outdoors.

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Locations

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Education & Board Certifications

Education

  • Graduate School: Harvard University, 2020
  • Fellowship: Cleveland Clinic, 2002
  • Residency: Stanford University, 1999
  • Medical Education: The Ohio State University College of Medicine and Public Health, 1995
  • Undergraduate: Northwestern University, 1991

Awards

  • Patient Safety Hero Award, Indianapolis Coalition for Patient Safety (2007)
  • Tony and Mary Hulman Health Achievement Award, Indiana Public Health Foundation (2007)
  • Cleveland Clinic Tarazi Award for Cardiovascular Research (2002)

Professional Memberships

American College of Cardiology

Research & Publications

See publications for this provider. (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Cleveland Clinic physicians and scientists collaborate with industry to advance medical breakthroughs. These partnerships help commercialize discoveries for public benefit while maintaining scientific integrity. To ensure transparency and minimize potential bias, Cleveland Clinic reviews these relationships and publicly discloses when physicians/scientists receive significant compensation for consulting, serve in fiduciary roles, receive royalties, or hold equity interests related to their work. We manage potential conflicts through approval processes, annual reporting, and targeted management plans.

As of 2026-04-13, Dr. Khot has reported the financial relationships with the companies listed below.

Royalty Payments. Dr. Khot receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Cardiac Protection Solutions, LLC

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Insurances Accepted

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Video

Ratings & Reviews

4.8 out of 5

63 ratings, 5 reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

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Courtesy Respect & Concern
Patient Rating of Doctor
    5 out of 5 stars
    Reviewed on 4/6/2026

    Dr Koht is the best!!!

    5 out of 5 stars
    Reviewed on 1/9/2026

    Great Dr I would highly recommend

    5 out of 5 stars
    Reviewed on 1/9/2026

    Dr. Khot was personable and attentive to my concerns. Highly recommended. I appreciated the follow up call the next day.

    5 out of 5 stars
    Reviewed on 12/2/2025

    Dr Khot is wonderful

    5 out of 5 stars
    Reviewed on 8/27/2025

    Perhaps the best Dr I have ever worked with