Zachary D. Burke, MD
Pediatric Orthopedic OncologyOrthopedic OncologyOrthopedic Surgery
Highlights
Age Groups Seen
- Adult
Languages
- English
Gender
MaleAbout Zachary D. Burke
Biography
Zachary Burke, MD is an orthopaedic oncologist in the Sarcoma Program of the Department of Orthopedic Surgery at the Cleveland Clinic. He completed his medical and orthopaedic training at UCLA where he was inducted into the Alpha Omega Alpha (AOA) honor society. He continued his training with a fellowship in orthopaedic oncology at Mount Sinai Hospital, Princess Margaret Cancer Center, and the Hospital for Sick Children at the University of Toronto. He specializes in pediatric and adult bone sarcoma, limb sparing surgical techniques, soft tissue sarcoma, benign tumors, and metastatic bone disease. Patient-centered care is his passion.
As a surgeon-scientist, Dr. Burke is very active in research in the Cleveland Clinic Lerner Research Institute (LRI) as a translational scientist. His research interests include osteosarcoma, novel sarcoma therapies, and clinical outcomes in orthopaedic sarcoma surgery. He completed a research fellowship at the Orthopaedic Hospital Research Center at UCLA and was awarded a Ruth L. Kirschstein National Research Service Award (T32) from the National Institutes of Health (NIH) in support of his work. He is a National Comprehensive Cancer Center (NCCN) Young Investigator awardee. He has numerous publications in both translational science and clinical research, has authored several book chapters, and has presented widely at national and international meetings. He is a member of the American Academy of Orthopaedic Surgeons (AAOS), Musculoskeletal Tumor Society (MSTS), and Connective Tissue Oncology Society (CTOS).
Dr. Burke lives in Cleveland and devotes his time outside of the Clinic to his wife, three children, and dog.
Locations
- Cleveland Clinic Children's Outpatient Center
- 8950 Euclid Avenue, Cleveland, OH 44106
- Get Directions
- A Building - Crile Building
- 2049 East 100th Street, Cleveland, OH 44106
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Education & Board Certifications
Education
- Fellowship: University of Toronto/Princess Margaret Cancer Center, 2022
- Residency: UCLA Medical Center, Department of Orthopedic Surgery, 2021
- Fellowship: Orthopedic Hospital Research Center, University of California, Los Angeles (UCLA), 2018
- Internship: University of California Los Angeles Medical Center (UCLA), 2016
- Medical Education: University of California, Los Angeles (UCLA), 2015
- Undergraduate: Pomona College, 2010
Board Certifications
- Orthopaedic Surgery: American Board of Orthopaedic Surgery, 2025
Research & Publications
See publications for this provider. (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)
Industry Relationships
Cleveland Clinic physicians and scientists collaborate with industry to advance medical breakthroughs. These partnerships help commercialize discoveries for public benefit while maintaining scientific integrity. To ensure transparency and minimize potential bias, Cleveland Clinic reviews these relationships and publicly discloses when physicians/scientists receive significant compensation for consulting, serve in fiduciary roles, receive royalties, or hold equity interests related to their work. We manage potential conflicts through approval processes, annual reporting, and targeted management plans.
As of 2026-03-20, Dr. Burke has reported no financial relationship with industry that is applicable to this listing.
In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.
Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.
* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.
Insurances Accepted
Video
Ratings & Reviews
4.9 out of 5
91 ratings, 14 reviewsThe Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
- 5 out of 5 starsReviewed on 2/19/2026
Dr Burke is a great listener and is very patient answering all my questions.
- 5 out of 5 starsReviewed on 2/5/2026
He is an amazing doctor!
- 5 out of 5 starsReviewed on 2/5/2026
I am very grateful to be a patient of Dr. Burke. He is so easy to talk to, and explains things In a way that Is easy to understand. He Is a gem!
- 5 out of 5 starsReviewed on 2/5/2026
Doctor Burke, And his team are AWESOME THANK THEM SO MUCH
- 5 out of 5 starsReviewed on 1/28/2026
Really like Dr Burke for all the above reasons
- 5 out of 5 starsReviewed on 12/2/2025
We have truly been blessed with Dr. Burke and his staff through this entire experience over the last 2 years! We could not have a better doctor to have with our son throughout this!
- 5 out of 5 starsReviewed on 10/9/2025
Dr Burke and his team are excellent
- 5 out of 5 starsReviewed on 10/9/2025
Dr. Burke is the best! He has always taken the time to listen and understand my concerns. He's very personable.
- 5 out of 5 starsReviewed on 8/11/2025
Dr. Burke is a gem! He is so professional with an excellent bed-side manner. Calm and low key but engaged.
- 5 out of 5 starsReviewed on 7/21/2025
Dr. Burke and his team have been caring, professional and friendly - I am so glad they have been my care providers during a very traumatic time
- 5 out of 5 starsReviewed on 7/2/2025
I have a very good experience with Dr Burke and his Associated.
- 5 out of 5 starsReviewed on 5/21/2025
Dr. Burke is exceptional
- 5 out of 5 starsReviewed on 5/21/2025
Dr and staff very kind and knowledgeable, making sure I understand my health care.
- 5 out of 5 starsReviewed on 5/2/2025
Liked Dr. Burke. Very friendly, professional, competent.